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The collagen fiber type transitions gradually from the outer to the inner layersthe outer layer is primarily composed of tension-resistant type I collagen, while moving inward, it gradually mixes with type II collagen extending to the edge of the nucleus pulposus, forming a tough ring structure that provides mechanical support to the disc by restricting NP displacement and resisting compressive loads

Prediction and site-specific mutagenesis of residues in transmembrane -helices of proton-pumping nicotinamide nucleotide transhydrogenases from Escherichia coli and bovine heart mitochondria

In: Casida JE, editor

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