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Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] (Li and Dou, 2000), cyclin-dependent kinase inhibitor 1A [CDKN1A/p21] (Pagano et al., 1995), and tumor protein p53 [TP53] (Lopes et al., 1997)), which are responsible for cell growth inhibition or cell death induction

Promotion of Angiogenesis: Adequate blood supply is vital for wound healing, delivering oxygen and nutrients to the damaged area

HUVECs plated on Matrigel in limiting medium with increasing concentrations of BPC157 formed more extensive tubes in a dose-dependent manner (Fig