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Moreover, TMAO activated the farnesoid X receptor (FXR) and small heterodimer partner (SHP), downregulating the expression of hepatic BA synthase cytochrome P450 family 7 subfamily A member 1 (CYP7A1), cytochrome P450 family 27 subfamily A member 1 (CYP27A1), and BA transporter organic anion-transporting polypeptide (OATP) in ApoE -/- mice ( Inflammatory response Atherosclerosis is also considered a chronic inflammatory disease because the endothelial inflammatory damage is ongoing throughout atherosclerosis progression ( in vitro studies of cultured endothelial progenitor cells (EPCs) by Chou et al

Together, they compound