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417 Intriguingly, cleaved type I collagen can initiate a DDR1-NF-B-p62-NRF2 cascade, increasing mitochondrial biogenesis in CAFs and promoting more metastasis-conducive invasive matrix structures

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136 In addition, acquired astrocytopathies are prominent in hepatic encephalopathy (in which astrocytes lose their homoeostatic capabilities 137 ) and in neuromyelitis optica, in which the astrocyte protein, AQP4 is the subject of autoimmune attack, leading to dysfunction and death of astrocytes resulting in pronounced inflammation and degeneration of neural tissue

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