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193 These subunits can directly interact with the activated GPCR or do so via intermediary proteins such as insulin receptor substrate

For example, neuronal activation is consistently associated with a 35 fold increase in astrocytic glucose uptake, as demonstrated by [ 3 H]2DG autoradiography (Pellerin and Magistretti, 1994)

One proposed mechanism involves the regulation of chromatin-bound copper ions, leading to oxidative DNA damage and fragmentation that triggers apoptotic pathways (289, 290)