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In practice, many supervised protocols combine these approaches

manipulated extracellular matrix remodeling thereby increased vessel compliance to alleviate arterial stiffness through suppressing MMP2, MMP9 and TGF-, inactivated energy sensor AMPK1 to block energy supply, relived ROS overeaccumulation mediated mitochondrial dysfunction, restrained cell pyroptosis to alleviate vascular inflammation in PVR by the inhibition of HSP47, NLRP3, caspase 1, IL-1 and IL-18

The associations of gut microbiota, endocrine system and bone metabolism

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