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Mutations in genes such as PINK1 (PARK6) and PARKIN (PARK2) are the most common cause of a form of Parkinsons disease that is difficult to diagnose and one of the earliest mutation-associated genes in familial autosomal recessive inheritance of PD (Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

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