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In vivo studies demonstrate that L-PC was able to significantly lower blood pressure in CyA treated animals and to prevent decrease creatinine clearance that normally results from CyA administration [57]

There is no gold standard assessment for identifying CIPN, but its diagnosis depends on patient history, symptoms, neurologic examination and type and dose of chemotherapy (Loprinzi et al., 2020

The elucidation of the pathogenesis of trimethylaminuria, a fish malodor syndrome, indicates that FMO3 is involved in TMA metabolism (Treacy et al., 1998)