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The interplay between dysregulated metabolites (e.g., SCFAs, itaconic acid) and oxidative stress is particularly critical, which directly affects immune cell function, inflammatory pathways, and end-organ damage

The consequences of not doing so can be severe, affecting not only individual health but also public health on a broader scale

Oral 7,8-dihydroxyflavone protects retinal ganglion cells by modulating the gut-retina axis and inhibiting ferroptosis via the indoleacrylic acid-AhR-ALDH1A3-FSP1 pathway

Enzymatic activity was determined spectrophotometrically by measuring the change in absorbance at 460 nm over 3 min (Rittirsch et al., 2008)