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These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial

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The patient has no contraindications to either compound, has had recent bloodwork confirming the absence of concerning metabolic or hormonal issues, and is willing to commit to a defined cycle with a defined review point

Modeling of Target Protein Structures The 3D structure files of the breast cancer biomarkers estrogen receptor (PDB:1QKU), progesterone receptor (PDB:2OVH), human epidermal growth factor receptor (PDB:3GOP), mind bomb (Mib) protein (PDB:4TSE), and Ki-67 (PDB:5J28) were then obtained from Protein Data Bank25 (Figure 2