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Imlunestrant is an oral, brain-penetrant selective estrogen receptor degrader with potent antitumor activity in ESR1 wild-type and mutant breast cancer

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The study demonstrated a significant improvement in progression-free survival in the entinostat group and very well tolerated with reduced risk in patient groups (133)

APP/PS1 mouse model of Alzheimer disease Mice that express two human transgenes for APP and PSEN1 (presenilin-1, also known as PS1), which contain the Swedish and L166P mutations, respectively