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Alzheimer, Parkinson, ferroptosis-related events, and Huntington disease, amyotrophic lateral sclerosis, Friedreich ataxia, traumatic brain injury, stroke, periventricular leukomalacia), namely iron accumulation in specific brain neuronal areas, reduced GSH activity or content, reduced GPX4 protein levels and cell loss.43 For instance, iron accumulates in areas susceptible to Alzheimer's disease that show plaque formation, even before aggregation of A and tau proteins which is also favored by oxidative stress.4446 Ferroptosis markers Therapeutic interventions benefit from the availability of biomarkers that provide information on the state of activation of the therapeutic target and monitor the effectiveness of the therapeutic intervention in suppressing the target

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