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In a randomized controlled clinical trial in 60 PD patients, 12 weeks of melatonin administration (10 mg/d) improved cognition, anxiety, and depression compared to patients on placebo [260]

After 3 weeks of intraperitoneal injection of berberine, the antioxidant activity of SOD, GPx, and CAT in rats was effectively restored, and MDA levels in lung tissue were reduced

Deficiency has been associated with hepatic encephalopathy, delayed wound healing, and impaired liver regeneration [49, 50]

In addition to ARE/EpRE, AP-1 and NFB, c-Myc has been identified to also contribute to the basal expression and induction of human GCL under oxidative stress [120]