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Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine

25 Half-Life and Active Metabolites Knowledge about the half-life of a drug is incomplete when the drug has active metabolites that prolong the action of the parent drug

Molecular mechanisms by which these phytochemicals might influence VDR signaling include modulating VDR expression and stability, enhancing co-activator recruitment, and crossing with other signaling pathways like PI3K/Akt, AMPK, and Nrf2 pathways (Cuenca-Mic and Aceves, 2020)

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