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The phosphodiesterase-4 inhibitor ibudilast increases brain levels of glial-derived neurotrophic factor and reduces microglial activation and production of pro-inflammatory cytokines (Charntikov et al., 2015)

Another strategy catalyzes glucose into gluconic acid and H 2 O 2 by exerting GOD-like or loaded GOD, which not only lowers the pH of the wound microenvironment to promote POD-like activity, but also replenishes the H 2 O 2 substrate [304,305,306,307,308,309]

L.YuB.TengB.VeeraperumalS.XuB.ZhongS.et al

Second, synergy with other agents (e.g., MI) is biologically plausible but clinically under-tested in factorial designs