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This is supported by evidence examining that posterior-cortical degeneration in PD is associated with more severe cognitive impairment in PD and is strongly associated with PDD (Pagonabarraga and Kulisevsky, 2012

Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] (Li and Dou, 2000), cyclin-dependent kinase inhibitor 1A [CDKN1A/p21] (Pagano et al., 1995), and tumor protein p53 [TP53] (Lopes et al., 1997)), which are responsible for cell growth inhibition or cell death induction

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