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Tiwari et al., 2015b)

In addition, PHDs were shown to absolutely rely on the co-factors oxygen (O 2 ) and iron (Fe 2+ ), thus, identifying PHDs as cellular oxygen sensors [43]

By exploring zincs influence on each component of the immune system, from innate responses mediated by neutrophils and macrophages to adaptive immunity regulated by T and B lymphocytes, this review underlines the importance of zinc for immune health in aging populations