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CTV 3LR, forward-5-GCATCGCATTGTCTGAGTAGGTGTCA-3, reverse-5- CTCGAAGACCTGTTGCTGCTCAGACAGCA-3 and HDAC9-forward-5- GGTGCTCTGCCTGCTTCTCAGCTGCA-3, CTV-IRES-reverse-5-CGCTTGAGGAGAGCCATTTGACTC-3

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lysosomes remained intact, demonstrating selectivity of organelle targeting In vivo tumour eradication pre-clinical studies have reported tumour eradication in nude mouse xenograft models following PNC-27 treatment Ovarian cancer models intraperitoneal mouse toxicity and maximum tolerated dose studies conducted alongside ex-vivo testing against primary patient-derived epithelial ovarian cancer cultures, demonstrating dose-dependent cytotoxicity including activity against chemotherapy-resistant ovarian cancer lines Haematological malignancy models near-complete cancer cell death reported in leukaemia models, including p53-deficient cells, via HDM-2 membrane binding Cervical cancer models confirmed selective killing of cervical cancer cells with no effect on untransformed cervical cells