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38 The binding is facilitated by receptors such as retinoic acid receptor-related orphan receptors , , and

Accordingly, in experimental models, supplements of omega-3 PUFAs have been demonstrated to exert neuro-protective and cardio-protective effects against hypothyroidism-induced damage, while attenuating hyperthyroidism-associated complications, including arrhythmias and hepatic dysfunction, thereby conferring protective actions on peripheral tissues across opposing states of thyroid dysfunction [127,130,131,132]