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This efficiency reflects the designers understanding that the triple receptor profile provides robust efficacy even at the earlier dose levels, allowing for a more streamlined escalation

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The BBB is present as a highly selective semi-permeable interface between blood and brain, possessing a defensive network of blood vessels and brain tissues that are complex, dynamic, and prevent the entry of harmful substances such as neurotoxic debris derived from blood, cells, and other microbial pathogens [6]

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