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If six months of consistent, properly-dosed application produces no noticeable change, alternative approaches may be needed

However, despite evidence suggesting the positive effects of improved tumor vascularization, there is also a risk of enhanced cancer cell activity and accelerated tumor growth [42]

Rare but serious risks include allergic reactions (including anaphylaxis in very rare cases), liver stress with prolonged high-dose use, and excessive skin lightening with unregulated dosing

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