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Intrinsic DILI is predictable and observed in preclinical studies 57, 58

10.1016/j.yjmcc.2017.03.002 115

Alveolar epithelial transport in the adult lung

The nanoparticles were prepared using an antisolvent precipitation method, producing spherical nanoparticles with an average size of 88.36 1.67 nm, a PDI of 0.047 0.007, and an encapsulation efficiency of 89.52 1.74%, coupled with a sustained-release profile where 93% of puerarin released over 48 h