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Microrna function is globally suppressed in mouse oocytes and early embryos

Additionally, in mice with a point mutation of PAR2 at Arg 38 to Glu (PAR2-R38E mice), PAR2 was rendered insensitive to activation at the canonical cleavage site by bacterial and endogenous trypsin-like proteases (21, 22, 30, 31)

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In addition to its role in GSH biosynthesis, the -glutamyl cycle also contributes to the degradation of extracellular glutathione and amino acid recycling through the action of membrane-associated -glutamyl transferase (GGT)