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All of this evidence comes from cell cultures and animal models

Fouad K, Pedersen V, Schwab ME, Brsamle C

Nilsen, J., Sandlie, I., Roopenian, D

Iron (Fe 2+ ) derived from hemoglobin metabolism and immune responses, implicated in early ALS pathogenesis via oxidative stress, contributes to motor neuron damage, exacerbating BBB permeability changes [244, 245]