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The microbiome and the gut-liver-brain axis for central nervous system clinical pharmacology: challenges in specifying and integrating in vitro and in silico models

Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, et al

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Initially identified through mutant screens for flies exhibiting persistent rhythmic behavior under constant light, jet was found to mediate the photic degradation of the core clock protein timeless, thereby facilitating circadian entrainment (Koh et al., 2006