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The average daily dose of ASA used chronically in the treatment of rheumatoid arthritis is 2,600 mg/day (Fries et al., A possible depressant effect in the animals in the present study, in which the rats were single housed without environmental enrichment, is unlikely as a cause of neuroinflammation, because as shown in Figure 6, control animals housed individually and receiving water as the only fluid do not show astrocyte or microglial abnormalities

Iran J Pharm Research: IJPR 21(1):e131577