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Description

Through promoting p38 phosphorylation in the MAPK pathway, TMAO activates inflammatory pathways and upregulates NOX4 to enhance oxidative stress and activate NLRP3 inflammasomes, resulting in renal inflammation

It is a literal building block of thyroid hormones

Although other metabolic factors, such as components of the metabolic syndrome (MetS), may also play a role, research indicates that hyperglycemia, a hallmark of type 2 diabetes, is a key mediator in the pathogenesis of DPN