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For tesamorelin, known adverse effects (based on US and Canadian prescribing information, as no UK Summary of Product Characteristics exists) include: Fluid retention (oedema, joint pain, carpal tunnel syndrome) Elevated blood glucose and reduced insulin sensitivity due to GH elevation Injection site reactions Raised IGF-1 levels active malignancy is a key contraindication

One study showed that the prevalence was 62% compared to 10% in the general population