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Diagnosis With a history of fava bean ingestion or of administration of a potentially hemolytic drug (see Table 18-3 ) followed by hemoglobinuria (see Table 18-4 ), the diagnosis is almost always straightforward, and it can be made quite confidently even before obtaining the final proof that the patient is deficient in G6PD (discussed later in this chapter)

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Besides, NOX5 is a key regulator of the phenotypic switching of VSMCs, and Ca 2+ can induce ROS production in VSMCs via NOX5 (90)