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Hot Topics Published: Neuropsychopharmacology volume 48 , pages 253254 (2023) Cite this article 1484 Accesses 6 Citations 3 Altmetric Metrics details Subjects Similar content being viewed by others Delivery of macromolecular therapeutics to the brain faces numerous obstacles, chief of which is transporting them across the blood brain barrier (BBB) of the central nervous system (CNS), in part due to the tight junctions between endothelial cells of the neurovasculature