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Excess visceral fat leads to increased production of pro-inflammatory cytokines, including TNF-, IL-6, and IL-17, as well as the following adipokines: leptin, visfatin, and resistin, which exacerbate inflammation (205)

Finally, at the FD location, significant differences were noticed pre- and post-surgery, with iBSC and y-intercept fluctuating over time

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Importantly, to the best of our knowledge, effects of therapeutic interventions applied in chronic degenerated discs have not been investigated and thus effects on wellestablished nociceptive nerve fiber innervation, among other processes, is not yet known