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Fmr1 -KO mice even increased the number of self-grooming episodes after oxytocin treatment [40]

In addition to per and tim , CLK/ CYC heterodimers activate genes that participate in additional clock feedback loops and a substantial number of clock output genes [7], [8]

This is due to the limited distance between the two arms of the ACE2 receptor, where the SARS-CoV-2 binding sites are located (Figures 11A,B), which cannot accommodate both RBDs dimerized via the C538 residue