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This trajectory mirrors aspects of human hepatic ontogeny, where hepatoblasts differentiate into functional hepatocytes and cholangiocytes before a subsequent phase involving mesenchymal cell expansion 32

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For the general structural formula presented above, and reproduced below for ease of reference, there are several different compounds which can be prepared according to the synthesis procedures described above and used for therapies described below

RongS.et al.1994Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation, 84