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This leads to changes in astrocytic glucose metabolism and glutamate transport, which in turn influence neuronal function by altering synaptic transmission and energy supply

Abbreviations ATC: anaplastic thyroid carcinoma AP: apurinic/apyrimidinic or abasic APE1: apurinic/apyrimidinic endonuclease 1 BER: base excision repair GSH: glutathione TME: tumor micro-environment AP probe-net: AP sites capture reagent WB: western blotting RIT: radioiodine therapy DNS: 2,4-dinitrobenzene sulfonamides MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide RMPI 1640: Roswell park memorial institute 1640 FBS: fetal bovine serum DMSO: dimethyl sulfoxide TBST: tris-buffered saline Tween GSS: glutathione enzyme DSBs: double-strand breaks NSCLC: non-small cell lung cancer References Lorimer C, Cheng L, Chandler R, Garcez K, Gill V, Graham K, et al

Blood 114(22):854-55, 2009

137161 Varga V, Janky R, Saransaari P, Oja SS (1994) Endogenous gamma-l-glutamyl and beta-l-aspartyl peptides and excitatory aminoacidergic neurotransmission in the brain