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Brain Lesions, Cerebral and Cerebellar Cortex, Hypothalamus/Thalamus, and Hippocampus Without therapy, the consistently downhill course of ligation of the bile duct at its entry into the duodenum in rats led to multiple organ lesions, widespread thrombosis, disturbed ECG and blood pressure, portal and caval hypertension, aortal hypotension, and in particular, intracranial (superior sagittal sinus) hypertension

Typical dosages explored in human pilot studies range from 5mg to 10mg, administered several times per week

The facility conducted GLP nonclinical safety studies, including guinea pig maximization sensitization (GPMT), acute systemic toxicity (AST), rabbit pyrogen, muscle implantation, hemolysis, and cytotoxicity tests

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