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Furthermore, mitochondrial dysfunction may exacerbate ECM instability by influencing collagen biosynthesis and post-translational modifications [16,104,105], thereby possibly contributing to hallmark features of hEDS such as joint hypermobility, skin hyperextensibility, and tissue fragility

Evaluation of phosphorus and non-phosphorus neutral oligonucleotide backbones for enhancing therapeutic index of gapmer antisense oligonucleotides

Recent Pat Inflammation Allergy Drug Discovery

Cross-organ sensitization seems to play a major role and, in this respect, data from the literature suggest that an altered gut microbiota is crucial in driving increased gut inflammation and permeability which may favor the transmission of noxious stimuly/agents to pelvic organs