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256 In contrast, the herpes simplex virus (HSV) preferentially infects astrocytes and oligodendrocytes, whereas microglia become reactive and neuroprotective through release of inflammatory mediators, such as interferon-, TNF-, IL-1, IL-6 and IL-8, RANTES and chemokine CXCL10

The most acceptable theory to explain the departure of the native -synuclein into the fibrillation pathway is the Liquid-Liquid phase separation (Ray et al., 2020)