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Lastly, we summarize inter-relationships between the regulatory networks of these various protein classes in ischemic stroke and discuss promising examples suggesting that they may have important roles in remote ischemic conditioning (RIC) as a novel paradigm in protection from brain ischemia

doi: 10.3389/fimmu.2025.1666233 Received 15 July 2025 Accepted 29 September 2025 Published 15 October 2025 Volume 16 - 2025 Edited by Tara Marlene Strutt, University of Central Florida, United States Reviewed by Huang Huang, Fudan University, China Xiao-Yong Man, Zhejiang University, China Updates Copyright 2025 Xu, Guo, Xu, Chen, Chen and Xu