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doi: 10.1038/cddis.2016.212 229 ShidaYNakazawaTMatsudaRMorimotoTNishimuraFNakamuraMet al

Although the FAERS database aids in detecting rare adverse events via spontaneous reporting, its propensity to overestimate unexpected adverse events linked to new therapies makes it inappropriate for comparative analysis of adverse event frequencies among pharmaceuticals

The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation

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