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GI healing: In colitis models, substantial reduction in mucosal damage scores and inflammatory infiltration by 34 weeks (Sikiric et al., 2003)

Because B12 is water-soluble and excess is excreted in urine, there is no established tolerable upper intake level and no known risk of toxicity at standard supplement doses

However, the study only recruited 52 patients, and patients who received oral clarithromycin+amikacin had more severe symptoms, which might have introduced bias into the results

In older people, B12 deficiency can sometimes be confused with symptoms of dementia, which is why it's always worth getting checked out if you have symptoms