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Similarly, in GV-stage mouse oocytes exposed to vitrification, there is an accumulation of mitochondrial ROS and an elevated rate of apoptosis, both of which are closely associated with mitochondrial dysfunction (47)

doi: 10.1189/jlb.3MR0316-106R 205 MaesMMihaylovaILeunisJC

This oxPPP increase can be phenocopied by treating cells with the carbon monoxide-producing molecule tricarbonylchloro(glycinatro)ruthenium, with release of carbon monoxide by HMOX1 seeming to promote PPP activity, although the biochemical mechanism remains unknown 99

These metabolites are also generated by colonic bacteria, following the ingestion of cooked cruciferous vegetables