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It was also found that Gb extract (EGb 761) shows an ability to protect neurons in animal models of Parkinsons disease [102]

Neuroscience and Behavioral Physiology, 23 (5), 480-485

Increased copper levels can upregulate inducible NO synthase (iNOS) expression, resulting in excessive NO production and peroxynitrite, a potent oxidant that causes further oxidative damage [86]

The respiratory chain in the inner mitochondrial membrane, where a portion of oxygen is reduced to superoxide radical anion by electron transport chain complexes, is one of the main sources of ROS within the organism