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3ad), with further elevation in CD38-associated features (including frequency, MdFI, MAD and SD) along chronological aging, as assessed by flow cytometry (Supplementary Fig

Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells