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PHGPxs role in many tissues has been described, including protection against oxidative stress against spermatozoa in the testes, as well as its neuroprotective properties illustrated by the link between GPx4 deficiency and Alzheimers and Parkinsons dementia [66]

Pharmacologic or genetic targeting of glutamine synthetase skews macrophages toward an M1-like phenotype and inhibits tumor metastasis

Even class II GRXs AtGRXS15, AtGRXS16 and HsGRX5 can catalyse the oxidation of roGFP2 by GSSG, although they fail to mediate its reduction 13,14,50