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They will determine the potential risks and benefits of continuing or discontinuing the medication

These findings indicate that DUSP22 downregulation and UBR2 induction promote T-cell-mediated inflammation and autoimmune disease in mice

Ribeiro FF, Xapelli S

So although the hypothesis / reason for interest in these compounds is never explicitly stated, the thought process seems to be similar to David Harris thought process: pH-sensitive proteases are doing something, and here are two orthogonal ways to inactivate them