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Description

Given the pivotal role of the system Xc -GSH-GPX4 axis in ferroptosis defense, inhibiting GPX4 or SLC7A11 has emerged as a promising strategy to induce ferroptosis in PDAC

USA 108 , 2115221157 (2011)

These changes reduce respiratory capacity by 50% and inhibit adipogenic differentiation (127, 128)

More recent research has confirmed hTERT upregulation as the mechanism in normal cell lines while identifying alternative pathways in cancer cell models (4)