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Available at: Acknowledgements We express our special gratitude to Markus Innil, Satu Malinen, Liina Lassila and Babette Hollmann for their technical assistance

Random forest-based premodeling was performed on all combinations of datasets and classifiers using these three scaling methods to evaluate their performance in terms of accuracy, recall, precision, F1 and Matthews correlation coefficient

Amylin receptor activators designed from this study need to be lipidated to increase pharmacokinetic profile for future studies similarly to the case of cagrilintide

Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]