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1 Introduction Rheumatoid arthritis (RA) is a multifactorial chronic autoimmune disease of unknown aetiology, which typically involves the joints and mostly manifests as symmetric polyarthritis in the large and small joints ( As a fundamental organelle, mitochondria are known as the energy centre of cells, which execute and coordinate various metabolic processes within cells and meet the energy demands of cells through the oxidative phosphorylation (OXPHOS) system

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This is structurally distinct from GHK alone, which lacks the copper ion that defines the GHK-Cu research compound

A 2026 review published in Frontiers in Aging noted that clinical data amounts to a handful of pilot studies and observational reports, none of which included placebo controls or randomization (source)