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While topically applied tranexamic is usually considered to be safe, the following precautions may still be considered: Care should be taken in cases of renal insufficiency due to the risk of accumulation Visual disturbances including visual impairment, vision blurred, impaired color vision have been reported with tranexamic acid

doi: 10.1111/jocd.13755

Its even upregulated right before meal times

Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Randomized, Double-Blinded, Double-Simulated Multicenter Study