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In a mouse model of colitis, royal jelly acid significantly reduced the expression of key inflammasome components, including TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1, and IL-18, while in THP1 cells, it inhibited LPS/ATP-induced inflammasome-mediated pyroptosis, thereby alleviating inflammation and associated colitis (Yang, et al., 2010)

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